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J Nat Rev Drug Discov 12(12):948962 Deacon CF (2019) Physiology and pharmacology of DPP-4 in glucose homeostasis and the treatment of type 2 diabetes

Glycerophospholipids contribute to MAFLD progression through oxidative stress activation and pro-inflammatory cytokine induction (e.g., IL-6, TNF-) ( Proteomic analysis revealed semaglutide-mediated downregulation of inflammatory mediators (STAT1, TGFB1I1) and apoptotic executor CASP3

Reduce pain 40-70%, improve mobility, slow progression

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Research demonstrates that GLP-1 receptors in the hypothalamus regulate energy intake and expenditure